Contacts

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DeGregorio Family Foundation Grant Recipients

2020-2021

$150,000

Yan-Yi Jiang, PhD
H. Phillip Koeffler, MD
Cedars-Sinai Medical Center

Master transcription factor-TP63 governs immune evasion of esophageal squamous cell carcinoma

Read the press release.

Download the press release PDF.

2020-2021

$200,000

Kishore Guda, DVM, PhD
Case Western Reserve University

Oncogenic TGFβ signaling as a new molecular paradigm and therapeutic vulnerability in esophageal cancer

Follow-on Funding: Anonymous $254,700

Read the press release.

Download the press release PDF.

2019-2020

$200,000

Sam S. Yoon, MD
Memorial Sloan Kettering in association with Sandra Ryeom, PhD, Associate Professor of Cancer Biology at University of Pennsylvania (currently at Columbia University)

Role of KRAS in gastric cancer stem-like cells in promoting metastasis, angiogenesis and chemotherapy resistance.

Follow-on Funding: Stand Up To Cancer $3M, Anonymous $200,000

Read the press release.

2019-2020

$200,000

Stephen Meltzer, MD
Johns Hopkins University, School of Medicine

Johannes Carolus (Hans) Clevers, MD, PhD
Princess Maxima Center of Pediatric Oncology

Create tumor organoids (miniaturized and simplified versions of organs) that replicate the tumor in a petri dish.

Read the press release.

2018-2019

$175,000

Adam Snook, PhD
Sidney Kimmel Cancer Center/Medical College

Study the effectiveness of CAR-T therapy as a treatment for gastroesophageal cancers

Follow-on Funding: Department of Defense $1,360,616

Read the press release.

2018-2019

$175,000

De-Chen Lin, PhD
Cedars-Sinai Department of Medicine

Deciphering transcriptional dysregulation in Barrett’s esophagus-associated neoplastic evolution

Follow-on Funding: Cedars-Sinai $75K, Alan B. Slifka Foundation: $260K; Department of Defense: $819,100, NIH $1,325,500, Cedars-Sinai $200K, Cedars-Sinai $100K

Publications:

Gut: “Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in esophageal adenocarcinoma”

Nature Communications: “Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression”

Gastroenterology: “Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma”

Nature Communications: "Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer”

Computational and Structural Biotechnology Journal: "Super-enhancer-mediated core regulatory circuitry in human cancer"

Nature Communications: "A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes” 

Cancer Research: "A transcriptional regulatory loop of master regulator transcription factors, PPARG, and fatty acid synthesis promotes esophageal adenocarcinoma”

Gastroenterology: "TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines”

Read the press release.

2017-2018

$175,000

Anisa Shaker, MD
Keck School of Medicine, USC

Human esophageal myofibroblast paracrine regulation of esophageal inflammation and carcinogenesis

Follow-on Funding: NIH $1.25M

Publications:

Scientific Reports: "Human esophageal myofibroblast secretion of bone morphogenetic proteins and GREMLIN1 and paracrine regulation of squamous epithelial growth"

2016-2017

$180,000

William Grady, MD
Fred Hutchinson Cancer Research Center

Screening study to better identify people at the highest risk for the most common form of esophageal cancer

Follow-on Funding: NIH $322,525, NIH $813,695; NIH $724,025, Evergreen Fund $50,000, Prevent Cancer Foundation $100,000

Publications:

PLoS Computational Biology: “A Molecular Clock Infers Heterogeneous Tissue Age Among Patient’s With Barrett’s Esophagus”

Clinical Epigenetics: “Identification of a key role of widespread epigenetic drift in Barrett’s esophagus and esophageal adenocarcinoma” 

Clinical Epigenetics: “Global DNA methylation patterns in Barrett’s esophagus, dysplastic Barrett’s, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use”

Gut: “Genome-wide methylation analysis reveals methylation subtypes of Barrett’s esophagus and esophageal adenocarcinoma"

Digestive Diseases and Science: “The Molecular Evolution of Metaplasia to Carcinoma in the Esophagus”

Blood: “Gene Expression-Based Discovery of Atovaquone as a STAT3 Inhibitor and Anti-Cancer Agent”

Clinical Cancer Research: “Novel Barrett’s Esophagus Screening Assays Based on Swallowable Devices: Will They Change the Game?” 

Read the research details.

2016-2017

$215,000

Ellen Beswick, PhD
University of New Mexico (currently at University of Utah)

Targeting MK2 for Treatment of Gastric Cancer

Follow-on Funding: NIH $228,750, Anonymous $600,000

Publication: Journal of Translational Medicine “The MK2 pathway is linked to G-CSF, cytokine production and metastasis in gastric cancer: a novel intercorrelation analysis approach”

Read the research details.

2015-2016

$200,000

Adam Bass, MD, Dana Farber Cancer Institute (currently at Columbia University) 
Timothy Wang, MD,
Columbia University

The role of Novel RHO Pathway Genomic Alterations in DGC

Follow-on Funding: $75K Department of Defense for a Fellow, NIH ~$2.2 million, Debbie’s Dream $50,000, Anonymous $999,094, The V Foundation for Cancer Research $600K

Read the research details.

2014-2015

$200,000

Phillip D. Smith, MD
University of Alabama, Birmingham

Elucidating Protective Mechanisms Against Gastric Cancer

Follow-on Funding: NIH $275K, NIH $1.25M, Veterans Affairs: $600K

Publications:

Mucosa Immunology: “Helicobacter pylori infection is associated with an altered gastric microbiota in children”

Gastroenterology: “Eradication of the Helicobacter pylori in Children Restores the Structure of the Gastric Bacterial Community to That of Noninfected Children"

Journal of Biological Chemistry: "Modulation of glycosyltransferase ST6Gal-I in gastric cancer-derived organoids disrupts homeostatic epithelial cell turnover”
 
Current Opinion in Physiology: "Interaction between H. pylori and the Gastric Microbiome: Impact on Gastric Homeostasis and Disease”

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2013-2014

$225,000

Tony Godfrey, MD
Boston University

Evaluating the Feasibility of a Molecular Cytology Approach for Management of Patients with Barrett’s Esophagus (BE)

Follow-on Funding: NIH: $5M

Publications:

Clinical Gastroenterology: “Combined EsophaCap Cytology and MUC2 Immunohistochemistry for Screening of Intestinal Metaplasia, Dysplasia and Carcinoma”

Surgical Clinics of North America: “The Molecular Biologic Basis of Esophageal and Gastric Cancers”

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2012-2013

$220,000

Theresa Pizarro, PhD
Case Western Reserve

Role of the Novel IL-1 Family Member, IL-33 in the Gastric-Metaplasia Carcinoma Sequence

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2012-2013

$20,000

Parry Guilford, MD
University of Otago

Identification of New Drugs for the Treatment and Prevention of Diffuse Gastric Cancer Using a High Throughput Compound Screening Approach

Follow-on Funding: $1M

Publications:

“Synthetic Lethal Screens Identify Vulnerabilities In GPCR Signaling and Cytoskeletal Organization in E-Cadherin-Deficient Cells”

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2011-2012

$165,000

David Frank MD, PhD
Dana Farber Cancer Institute

Targeting Gastroesophageal Cancer through Dual Transcription Inhibitors

Follow-on Funding: NIH $6 million, in collaboration with Drs. Bass and Rustgi at University of Pennsylvania, Anonymous $196,300 

Publications:

Molecular Cell: “Fold Change of Nuclear NF-IB Determines TNF-Induced Transcription in Single Cells”

Current Opinion in Oncology: “Targeting Transcription Factors: Promising New Strategies for Cancer Therapy”

Molecular Cancer Research: "STAT3 modulates NF-kB activity by upregulating negative regulators of NF-kB: Rationale for combination therapy targeting oncogenic transcription factors”

“IL-6 mediates cross-talk between activated fibroblasts and tumor cells in the tumor microenvironment: applications in therapeutic intervention”

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2011-2012

$100,000

Manish Shah, MD
Weill Cornell Medical College

The Next Generation Sequencing to Evaluate Transcriptomic Changes Associated with H. Pylori Infection and Gastric Cancer Carcinogenesis

Follow-on Funding: $100K Advanced Digestive Care, 996k Starr Foundation Dr. Shah as principal investigator with collaboration from Dr. Adam Bass, Broad Institute, and Dr. Eric Pamer, MSKCC

Publications:

”Identification of the Gastric Microbiome samples from using whole genomic sequencing”

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2009-2010

$100,000

Matthew Meyerson, MD, PhD and Dr. Adam Bass, MD (Dr. Bass currently at Columbia University)
Dana Farber Cancer Institute

Research to conduct investigations into the genes and the genetic differences which are drivers of esophageal cancer

Follow-on Funding: NHGRI ~$1 million, ~1.2 million, ACS ~$660,000, ~$2 million

Publications:

Cancer Research: “Gastrointestinal Adenocarcinomas of the Esophagus, Stomach and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis”

Nature Genetics: “Exome and Whole Sequencing of Esophageal Adenocarcinoma identifies recurrent driver events and mutational complexity”

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2006 - 2009

$500,000

Memorial Sloan Kettering Cancer Center

Early Onset and Familial Gastric Cancer Registry

Follow-on Funding: $408K

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*Follow-on funding is additional funding at a later stage.