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12th Annual DeGregorio Family Foundation Grant Award for Cancers of the Esophagus and Stomach

The DeGregorio Family Foundation for Gastric and Esophageal Cancer is pleased to announce our 12th annual funding opportunity for gastroesophageal malignancies. The Foundation seeks to promote and facilitate collaborative research on the pathogenesis, early diagnosis, and treatment of upper gastrointestinal malignancies. We support high quality, innovative, and transformative translational and bench research to improve the understanding of the biology of these diseases, identification of potential novel therapeutic targets, or in the development and evaluation of novel biomarkers for early diagnosis and treatment. Pre-clinical research, basic mechanistic studies, genomic/epigenomic studies, as well as epidemiologic studies may also be supported

Special Grant Awards

Applications currently under review

Thanks to a generous anonymous donor, this year we are able to support up to two additional grants for gastroesophageal malignancies with the same guidelines as above and the same protocol.  These Special Grant Awards have an earlier deadline of July 15, 2021.

12th Annual Grant Award

Application Timeline and Grant Details - Applications Currently Under Review

Deadline: November 2, 2021. Up to $250,000 over two years will be awarded.
Funding Period: January 15, 2022 – January 14, 2024
Amount: $250,000 for entire grant period. (Indirect costs cannot exceed 10%, and the entire grant cannot exceed $250,000.)

Deadline for applications: Tuesday, Nov. 2, 2021

Eligibility: The Foundation must be associated with an academic or medical institution possessing a tax-exempt status under section 501(c)(3) of the IRS code. 
We are not accepting applications from postdocs.  Research projects must not be funded currently under a separate mechanism.

Research projects are selected through a rigorous review process, and project goals must align with the DeGregorio Family Foundation’s mission. The Foundation’s application review process is guided by its Scientific Advisory Board. Criteria for successful grants are impact, the likelihood of completion, and making a significant contribution to understanding, diagnosing. or treating gastric or esophageal malignancies. The intention of this award is to provide seed funding for research in upper GI malignancies. Funded applicants are expected to apply for subsequent peer-reviewed support (i.e. NIH or similar agency).

We wish all the applicants luck and we hope to announce winners by mid-January.

Accountability:
Funding will be divided into three installments. The first installment will be provided when appropriate institutional approvals are submitted and the study is underway. The 2nd installment is contingent upon submission and review of an interim report at 1 year, and the final installment will be contingent upon receipt of a final study report.

Any publications or presentations resulting from this research must be acknowledged.

Applications Timeline and Further Details

2022 Special Grant Award

(stay tuned for details on our 13th Annual Grant Award for $250,000 later in the year)

The DeGregorio Family Foundation is pleased to announce an RFA for $1-$1.5 million-dollar grants targeting research aimed at curing gastroesophageal cancer.

Request for Applications
Despite the recent drug approvals for the treatment of gastric and esophageal carcinoma, these diseases continue to have a high morbidity and mortality. The DeGregorio Foundation is focused on supporting clinical research that has the potential to greatly impact patient care and significantly advance the management of patients with gastric or esophageal carcinoma. We are requesting grant applications that are translational in nature, or that may involve a clinical trial, to improve the treatment of patients with gastric or esophageal cancer. For example, proposals that examine a new treatment paradigm, a novel therapeutic agent, or are developing a new approach to target patients for treatment will be favorably considered. The Torrey Coast Foundation will match funds from the DeGregorio Family Foundation to support the grant. Awardees should be willing to collaborate with the Torrey Coast Foundation GEMINI group www.teamgemini.org. Grant applications with multi-site collaboration are also encouraged.

Funding – $1M to $1.5M over 3 years. Funding for clinical trials could be delayed for up to a year due to the logistics of setting up such trials.

Indirect costs – 15%

All applicants are required to submit a letter of intent (no more than 1 page) indicating the title, less than 300-word abstract, and institutions involved (due date June 10). The final grant is due July 22.

Applications Timeline and Further Details

Deadline: Letter of Intent, June 10, 2022; Proposal, July 22, 2022. Up to $1.5 Million over three years will be awarded.

Funding Period: September 1, 2022 – August 31, 2025. Funding for clinical trials could be delayed for up to a year due to the logistics of setting up such trials.

Amount: $1 million-$1.5 million. For entire grant period. (Indirect costs cannot exceed 15% and the entire grant cannot exceed $1.5 million)

Eligibility: The Foundation must be associated with an academic or medical institution possessing a tax-exempt status under section 501(c)(3) of the IRS code.

We are not accepting applications from postdocs.

Please do not submit the same grant application to the DeGregorio Family Foundation as from a previous grant cycle unless the Foundation has specifically requested that you do so.

Research projects must not be funded currently under a separate mechanism. Research projects are selected through a rigorous review process. The Foundation’s application review process is guided by its Scientific Advisory Board headed by Dr. Manish A. Shah.

We wish all the applicants luck and we hope to announce winners by early September.

Accountability: Funding will be divided into three installments. The first installment will be provided when appropriate institutional approvals are submitted and the study is underway. The 2nd installment is contingent upon submission and review of an interim report at 1 year, the 3rd installment will be contingent upon submission and review of an interim report at 2 years.  A final study report must be completed.

Any publications or presentations resulting from this research must be acknowledged.

Any questions should be sent in writing to sarah@degregorio.org and will be answered in an expeditious manner.

Letter of Intent

Please use our form to upload your Letter of Intent. 

Grant Application

Grant application PDF Form

Grant application Word Doc

Please use our form to upload your application and supporting files.

For Grant Winners:

Interim Progress Report

Grants Impact

Learn more about how DeGregorio Family Foundation Turns Research into Action™

100% of the DFF funds go directly to research.

The DFF Scientific Advisory Board looks for the best research that will attract follow-on funding

Doctors use research for early diagnosis

Grant recipients provide progress reports publish papers and attract follow-on funding to implement research.